| | | | | PRGF | | Reference: | Leppanen VM, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, Lankinen H, Goldman A, Ballmer-Hofer K, Alitalo KStructural determinants of growth factor binding and specificity by VEGF receptor 2Proc. Natl. Acad. Sci. U. S. A. v107, p.2425-2430 Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel formation through activation of three receptor tyrosine kinases, VEGFR-1, -2, and -3. The extracellular domain of VEGF receptors consists of seven immunoglobulin homology domains, which, upon ligand binding, promote receptor dimerization. Dimerization initiates transmembrane signaling, which activates the intracellular tyrosine kinase domain of the receptor.... » View full abstract | | Description: | Crystal Structure Of Vegf-C In Complex With Domains 2 And 3 Of Vegfr2. | | Deposition: | 2010/1/8 | | | | Author: | Leppanen VM, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, Lankinen H, Goldman A, Ballmer-Hofer K, Alitalo K | | | Taxonomy: | Homo sapiens | | Related Structure: | VAST | | | Molecular components in the MMDB structure are listed below and may include macromolecular chains, 3D domains, protein classifications (domain families), and ligands, as available. Mouse over each icon for more information on the component. | Chemical | | | | | Part Of N-Linke.. | | | 20 occurrences | | | | | | Acetylglucosami.. | | | 13 occurrences | | | | Cs+ | | Cesium Cation | | 2 occurrences | | | Citing MMDB: Wang Y, Addess KJ, Chen J, Geer LY, He J, He S, Lu S, Madej T, Marchler-Bauer A, Thiessen PA, Zhang N, Bryant SH. "MMDB: annotating protein sequences with Entrez's 3D-structure database.", Nucleic Acids Res. 2007 Jan; 35(Database issue): D298-300. Chen J, Anderson JB, DeWeese-Scott C, Fedorova ND, Geer LY, He S, Hurwitz DI, Jackson JD, Jacobs AR, Lanczycki CJ, Liebert CA, Liu C, Madej T, Marchler-Bauer A, Marchler GH, Mazumder R, Nikolskaya AN, Rao BS, Panchenko AR, Shoemaker BA, Simonyan V, Song JS, Thiessen PA, Vasudevan S, Wang Y, Yamashita RA, Yin JJ, Bryant SH. "MMDB: Entrez's 3D-structure database", Nucleic Acids Res. 2003 Jan; 31(1): 474-7. | |
